Author

Kimberly D. Insigne

University of California, Los Angeles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:DNA methylation· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Organism:E. coli· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Sriram KosuriiD· 5 shared Jessica E. DavisiD· 3 shared Eric M. JonesiD· 2 shared Guillaume UrtechoiD· 2 shared Alan P. BoyleiD· 1 shared Arielle D. TrippiD· 1 shared Christina P. Burghard· 1 shared Daniel Bryan GoodmaniD· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersGenetic & Genomic Medicine

Sriram KosuriORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants

Jessica C. McAfee, Sool Lee, Jiseok Lee, Jessica Bell, Oleh Krupa, Jessica E. Davis, Kimberly D. Insigne, Marielle L. Bond, Nanxiang Zhao, Alan P. Boyle, Douglas H. Phanstiel, Michael I. Love, Jason L. Stein, W. Brad Ruzicka, José Dávila-Velderrain, , Hyejung Won

The paper uses MPRA to identify functional regulatory variants associated with schizophrenia and shows they differ from eQTLs in genomic location and regulatory impact.

Cell Genomics · Sep 15, 2023Peer-reviewedGenetic & Genomic Medicine

Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems

Timothy C. Yu, Winnie L. Liu, Marcia S. Brinck, Jessica E. Davis, Jeremy Shek, Grace Bower, Tal Einav, Kimberly D. Insigne, Rob Phillips, Sriram Kosuri, Guillaume Urtecho

The paper profiles 8,269 IPTG-inducible promoters to model gene expression and identify optimal promoter architectures for predictable transcriptional control.

Nature Communications · Jan 12, 2021Peer-reviewedSynthetic Biology

Multiplexed dissection of a model human transcription factor binding site architecture

Jessica E. Davis, Kimberly D. Insigne, Eric M. Jones, Quinn B Hastings, Sriram Kosuri

The paper investigates how transcription factor binding site architecture influences transcriptional activity using synthetic regulatory elements in a massively parallel reporter assay.

bioRxiv · May 13, 2019 · PreprintGenomics

Many rare genetic variants have unrecognized large-effect disruptions to exon recognition

Rocky Cheung, Kimberly D. Insigne, David Yao, Christina P. Burghard, Eric M. Jones, Daniel Bryan Goodman, Sriram Kosuri

The paper identifies rare genetic variants that cause large disruptions to exon recognition, using a new assay called MFASS, and finds most of these variants are not in canonical splice sites.

bioRxiv · Mar 10, 2018 · PreprintGenetics

Systematic Dissection of Sequence Elements Controlling σ70 Promoters Using a Genomically-Encoded Multiplexed Reporter Assay in E. coli

Guillaume Urtecho, Arielle D. Tripp, Kimberly D. Insigne, Hwangbeom Kim, Sriram Kosuri

The paper develops a multiplexed assay to study σ70 promoter function in E. coli, finding that sequence elements explain most of the variance in promoter strength.

Biochemistry · Feb 1, 2018Peer-reviewedMolecular Biology