Human Topoisomerase IIα Promotes Chromatin Condensation Via a Phase Transition
Meiling Wu, Curtis Beck, Joyce H. Lee, Robert M. Fulbright, Joshua Jeong, James T. Inman, Mitchell V Woodhouse, James M. Berger, Michelle Dong Wang
This study identifies a new role for human topoisomerase IIα in promoting chromatin condensation through a polymer-collapse phase transition, independent of its catalytic activity.
bioRxiv · Oct 15, 2024 · PreprintBiophysics