Author

Thy Truong

Brigham Young UniversityORCID 0000-0002-6675-7685Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Amanda J. GuiseiD· 3 shared Edward D. PloweyiD· 3 shared Ryan KellyiD· 3 shared Daisha Van Der Watt· 2 shared Hannah Boekweg· 2 shared Samuel PayneiD· 2 shared Daniel López‐FerreriD· 1 shared Khatereh Motamedchaboki· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioinformatics

Amanda J. GuiseORCID

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3 papers

Recent·Most cited

Features of peptide fragmentation spectra in single cell proteomics

Hannah Boekweg, Daisha Van Der Watt, Thy Truong, S. Madisyn Johnston, Amanda J. Guise, Edward D. Plowey, Ryan Kelly, Samuel Payne

This study examines how peptide fragmentation spectra differ between single cell and bulk proteomics, identifying key changes that affect peptide identification.

Journal of Proteome Research · Dec 17, 2021Peer-reviewedBioinformatics

Benchmarking PSM identification tools for single cell proteomics

Daisha Van Der Watt, Hannah Boekweg, Thy Truong, Amanda J. Guise, Edward D. Plowey, Ryan Kelly, Samuel Payne

This study benchmarks peptide spectrum match identification tools for single cell proteomics and finds MetaMorpheus performs best at 1% FDR, with post-processing ML improving results by up to 40%.

bioRxiv · Aug 17, 2021 · PreprintBioinformatics

Ultrasensitive single-cell proteomics workflow identifies >1000 protein groups per mammalian cell

Yongzheng Cong, Khatereh Motamedchaboki, Santosh A. Misal, Yiran Liang, Amanda J. Guise, Thy Truong, Romain Huguet, Edward D. Plowey, Ying Zhu, Daniel López‐Ferrer, Ryan Kelly

This paper introduces an ultrasensitive single-cell proteomics workflow that identifies over 1000 protein groups per mammalian cell using advanced mass spectrometry techniques.

Chemical Science · Nov 17, 2020Peer-reviewedSystems Biology