Romain Huguet

Real-time library search increases cross-link identification depth across all levels of sample complexity

The paper introduces real-time library search (RTLS) to improve cross-link identification in XL-MS by leveraging intensity ratios of diagnostic peaks, enhancing identification depth in complex samples.

A novel multifunctional role for Hsp70 in binding post-translational modifications on clients

This paper uses cross-linking mass spectrometry to characterize Hsp70 interactions in budding yeast, revealing self-association, multi-point client interactions, and novel PTMs critical for client function.

Ultrasensitive single-cell proteomics workflow identifies >1000 protein groups per mammalian cell

This paper introduces an ultrasensitive single-cell proteomics workflow that identifies over 1000 protein groups per mammalian cell using advanced mass spectrometry techniques.