Edward D. Plowey

The paper uses a mouse model to study ARIA induced by anti-Aβ antibodies, showing MRI and histopathologic features similar to human ARIA.

iSCALE predicts super-resolution gene expression and annotates tissue architecture in large tissues, revealing features missed by conventional spatial transcriptomics.

This study compares snRNAseq data from C9orf72, SOD1, and sporadic ALS spinal cords, identifying shared and distinct molecular features across cell types.

This study develops an antibody transport vehicle targeting the transferrin receptor to improve brain delivery of anti-amyloid antibodies, reducing ARIA-like lesions and vascular inflammation in a mouse model.

This study examines how peptide fragmentation spectra differ between single cell and bulk proteomics, identifying key changes that affect peptide identification.

This study benchmarks peptide spectrum match identification tools for single cell proteomics and finds MetaMorpheus performs best at 1% FDR, with post-processing ML improving results by up to 40%.

The paper calculates the sample size requirements for detecting proteome dynamics in single cell proteomics time course experiments.

This paper introduces an ultrasensitive single-cell proteomics workflow that identifies over 1000 protein groups per mammalian cell using advanced mass spectrometry techniques.

The paper examines the correlation between CSF sTREM2 and CSF tau levels in Parkinson’s disease and finds that sTREM2 is elevated in PD subgroups with abnormal tau but not Aβ.