Author

Jenu Varghese Chacko

University of Wisconsin–MadisonORCID 0000-0002-6676-0358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:spatial domain detection· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

Adan Guerrero· 1 shared Christopher D. WoodiD· 1 shared Diana M. Vázquez-EncisoiD· 1 shared Esley TorresiD· 1 shared Haydee O. Hernández· 1 shared Iván Coto HernándeziD· 1 shared Jayne M. SquirrelliD· 1 shared Jyoti J. WattersiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Adan Guerrero

Mutual co-authors in cluster

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2 papers

Recent·Most cited

PSF-Driven Spatio-Temporal Blending in Fluorescence Lifetime Imaging Microscopy and Its Mitigation via Mean-Shift Super-Resolution-Based Masking.

Mario González-Gutiérrez, Diana M. Vázquez-Enciso, Nicolas Mateos, Wonsang Hwang, Esley Torres, Haydee O. Hernández, Jenu Varghese Chacko, Iván Coto Hernández, Pablo Loza‐Álvarez, Christopher D. Wood, Adan Guerrero

This paper introduces a method to mitigate spatio-temporal blending in FLIM by using MSSR-based masking, improving spatial resolution while preserving lifetime accuracy.

ACS Photonics · Sep 14, 2026Peer-reviewedBiophysics

Metabolic response of microglia to amyloid deposition during Alzheimer's disease progression in a mouse model

Kaitlyn M. Marino, Jayne M. Squirrell, Jenu Varghese Chacko, Jyoti J. Watters, Kevin W. Eliceiri, Tyler Kent Ulland

This study uses FLIM to analyze metabolic changes in microglia of 5XFAD mice, revealing increased glycolysis and a novel fluorescence component linked to AD pathology.

bioRxiv · May 12, 2023 · PreprintNeuroscience