Aayatti Mallick Gupta

HepI and OpsX are functionally coupled but evolutionarily asymmetric heptosyltransferase variants: ecological transitions and operon modularization drive divergent constraints and flexibility

This paper compares HepI and OpsX heptosyltransferases in Gram-negative bacteria, finding they are functionally linked but evolve asymmetrically due to ecological and genomic factors.

Structural Adaptations of HepI Enzymes in Proteobacteria: Insights into Evolutionary Resilience and Functional Dynamics

This study identifies sequence motifs in HepI enzymes that correlate with LPS structural features and reveals structural adaptations linked to evolutionary resilience and functional versatility in proteobacteria.

Conserved inter-domain interactions drive trans-Golgi network localisation and trafficking of homologous copper-ATPases

This study identifies conserved inter-domain interactions critical for TGN localization and copper trafficking in Cu-ATPases by analyzing chimeric proteins and evolutionary relationships.

Unraveling the Interactions between Human DPP4 Receptor, SARS-CoV-2 Variants, and MERS-CoV, converged for Pulmonary Disorders Integrating through Immunoinformatics and Molecular Dynamics

The paper investigates interactions between SARS-CoV-2 variants, MERS-CoV, and DPP4 using molecular docking and simulation to identify mutations that enhance DPP4 binding and disease severity.

Immune escape facilitation by mutations of epitope residues in RdRp of SARS-CoV-2

The paper investigates how mutations in epitope residues of SARS-CoV-2 RdRp affect antibody escape by analyzing structural changes using molecular dynamics simulations.

Distribution of Sigma factors delineates segregation of virulent and avirulent Mycobacterium

The paper analyzes sigma factor distribution across 40 Mycobacterium species to identify patterns associated with pathogenicity and classifies species based on their sigma factor profiles.