Sukhendu Mandal

A Novel MicroRNA-Odorant Receptor Axis Governs Neural Progenitor Cell Proliferation in Zebrafish CNS

This study identifies a novel miRNA-odorant receptor axis that regulates ERG cell proliferation in zebrafish spinal cord after injury.

An Indole Dimer Antifungal Metabolite from a Rice Seed Endophyte Inhibits Ergosterol Biosynthesis in Fungal Pathogens

This paper identifies SM06, an antifungal metabolite from a rice seed endophyte, which inhibits ergosterol biosynthesis in fungal pathogens and suppresses plant disease.

Immune escape facilitation by mutations of epitope residues in RdRp of SARS-CoV-2

The paper investigates how mutations in epitope residues of SARS-CoV-2 RdRp affect antibody escape by analyzing structural changes using molecular dynamics simulations.

Structural basis of ECF-sigma-factor-dependent transcription initiation.

This study reports crystal structures of ECF-sigma-factor-dependent transcription initiation complexes in Mycobacterium tuberculosis, revealing conserved interactions with RNAP and promoter DNA.

Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3)

This paper reports the cryo-EM structure of Mycobacterium tuberculosis RNAP holoenzyme bound to fidaxomicin, revealing its unique binding site and mechanism of transcription inhibition.

Distribution of Sigma factors delineates segregation of virulent and avirulent Mycobacterium

The paper analyzes sigma factor distribution across 40 Mycobacterium species to identify patterns associated with pathogenicity and classifies species based on their sigma factor profiles.

Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition

This study reports crystal structures of Mycobacterium tuberculosis RNA polymerase with and without antituberculosis drugs, revealing a new class of inhibitors and their binding mechanisms.