Hiroaki Misonou

This study investigates how phosphorylation patterns in the proline-rich region of Tau affect its microtubule-binding dynamics in neurons using FRAP and computational modeling.

This study identifies the S/P region of MAP2 as critical for its localization in dendrites, revealing that cytoplasmic dynein-mediated transport maintains this localization through an intermittent active transport mechanism.

The paper develops an experimental system for proper axonal tau localization and identifies phosphorylation of the proline-rich region 2 as critical for this process.

This study shows that ectopic expression of human tau in mice leads to abnormal somatodendritic distribution, while knock-in mice show normal axonal localization due to developmental expression patterns.