BioengineeringNature CommunicationsPeer-reviewed
Synthesis of ionizable lipopolymers using split-Ugi reaction for pulmonary delivery of various size RNAs and gene editing
Kseniya Yu. Vlasova, A. Kerr, Nathan D. Pennock…·Gaurav Sahay
The paper develops a method to deliver various RNA therapeutics, including mRNA and CRISPR-Cas9, to the lung using lipopolymer-lipid hybrid nanoparticles, showing improved efficacy and reduced toxicity.