Synthesis of ionizable lipopolymers using split-Ugi reaction for pulmonary delivery of various size RNAs and gene editing
Kseniya Yu. Vlasova, A. Kerr, Nathan D. Pennock, Antony Jozić, Deepak Kumar Sahel, Milan Gautam, Namratha Turuvekere Vittala Murthy, A. Roberts, M. W. Ali, Kelvin D. MacDonald, J. M. Walker, Robert Luxenhofer, Gaurav Sahay
The paper develops a method to deliver various RNA therapeutics, including mRNA and CRISPR-Cas9, to the lung using lipopolymer-lipid hybrid nanoparticles, showing improved efficacy and reduced toxicity.
Nature Communications · Apr 29, 2025Peer-reviewedBioengineering