Diethard Tautz

A reassessment of positive growth effects of expressed random sequence clones in E. coli

The paper reassesses the positive growth effects of random sequence clones in E. coli, showing some clones confer genuine fitness advantages independent of vector artifacts or clone competition.

Full-length RNA transcript sequencing traces brain isoform diversity in house mouse natural populations

The paper sequences full-length RNA transcripts from multiple mouse species to catalog isoform diversity and refine genome annotation.

Patterns of extreme outlier RNA expression in population data reveal sporadic over-activation of genes with co-regulated modules in subsets of individuals

The paper identifies sporadic over-activation of co-regulated genes with extreme outlier RNA expression in multiple species and tissues, showing these patterns are not inherited but may reflect gene regulatory network dynamics.

Fast evolutionary turnover and overlapping variances of sex-biased gene expression patterns defy a simple binary sex-classification of somatic tissues

The paper examines sex-biased gene expression patterns in somatic tissues of mice and humans, finding rapid evolutionary turnover and overlapping variances that challenge a binary sex classification.

Testing the accuracy of 3D automatic landmarking via genome-wide association studies

This study evaluates the accuracy of 3D automatic landmarking by comparing its ability to detect QTLs in mouse skulls and jaws with a semi-automatic method.

The imprinted lncRNA Peg13 regulates sexual preference and the gender-specific brain transcriptome in mice

The paper was withdrawn due to data inconsistencies and unsupported conclusions about the role of Peg13 in regulating sexual preference and brain transcriptome in mice.

The mutational load in natural populations is significantly affected by high primary rates of retroposition

The study shows that retroposition rates in natural mouse populations are much higher than previously thought, with most events being deleterious and affecting gene expression.

Testing implications of the polygenic model for the genetic analysis of loci identified through genome-wide association

The paper tests if genes not identified in GWAS can still influence traits through modifier interactions, finding that many random genes also affect traits.

Studying the dawn of de novo gene emergence in mice reveals fast integration of new genes into functional networks

The paper studies three newly emerged genes in mice, showing they quickly integrate into functional networks without extensive adaptive changes.

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

This study shows that high mitochondrial heteroplasmy in mice reduces lifespan and impairs glucose metabolism.