Heparan sulfate modified proteins affect cellular processes central to neurodegeneration and modulate presenilin function
Nicholas Schultheis, Alyssa Connell, Alexander Kapral, Robert J. Becker, Richard Mueller, Shalini Shah, Mackenzie O’Donnell, Matthew Roseman, Lindsey Swanson, Sophia DeGuara, Weihua Wang, Fei Yin, Tripti Saini, Ryan J. Weiss, Scott B. Selleck
The paper investigates how heparan sulfate-modified proteoglycans influence AD-related pathways by modulating presenilin function in human cells, mouse astrocytes, and Drosophila.
iScience · Jul 1, 2024Peer-reviewedNeuroscience