Linda S. Forero-Quintero

The paper uses single-cell experiments and stochastic modeling to uncover mechanisms of GR dynamics and DUSP1 transcription regulation in response to glucocorticoids.

The paper proposes a computational framework to analyze single-cell experiments and optimize design to extract fluctuation information while reducing measurement noise.

The paper uses live-cell imaging to study RNA polymerase II phosphorylation dynamics at a single gene, revealing spatial and temporal organization of phosphorylation clusters during transcription.