Computational design of developable therapeutic antibodies: efficient traversal of binder landscapes and rescue of escape mutations
Frédéric A. Dreyer, Constantin Schneider, Aleksandr Kovaltsuk, Daniel Cutting, Matthew J. Byrne, Daniel Allen Nissley, Newton Wahome, Henry Kenlay, Claire Marks, David Errington, Richard J. Gildea, David Damerell, Pedro A. G. Tizei, Wilawan Bunjobpol, John F. Darby, , Charlotte Mary Deane
This paper presents a computational pipeline for designing therapeutic antibodies using AI and physics-based methods, showing improved binding and developability across SARS-CoV-2 variants.
bioRxiv · Oct 3, 2024 · PreprintBioinformatics