Author

Daniel Cutting

ORCID 0000-0002-7395-7802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Charlotte Mary DeaneiD· 2 shared Constantin SchneideriD· 2 shared Aleksandr KovaltsukiD· 1 shared Alexandre M. J. J. BonviniD· 1 shared Claire MarksiD· 1 shared Daniel Allen NissleyiD· 1 shared Daniel L. HurdissiD· 1 shared David DamerelliD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBioinformatics

Charlotte Mary DeaneORCID

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2 papers

Recent·Most cited

Computational design of developable therapeutic antibodies: efficient traversal of binder landscapes and rescue of escape mutations

Frédéric A. Dreyer, Constantin Schneider, Aleksandr Kovaltsuk, Daniel Cutting, Matthew J. Byrne, Daniel Allen Nissley, Newton Wahome, Henry Kenlay, Claire Marks, David Errington, Richard J. Gildea, David Damerell, Pedro A. G. Tizei, Wilawan Bunjobpol, John F. Darby, , Charlotte Mary Deane

This paper presents a computational pipeline for designing therapeutic antibodies using AI and physics-based methods, showing improved binding and developability across SARS-CoV-2 variants.

bioRxiv · Oct 3, 2024 · PreprintBioinformatics

Towards the accurate modelling of antibody-antigen complexes from sequence using machine learning and information-driven docking

Marco Giulini, Constantin Schneider, Daniel Cutting, Nikita Desai, Charlotte Mary Deane, Alexandre M. J. J. Bonvin

The paper evaluates how machine learning-generated antibody and antigen structures can improve antibody-antigen complex modelling using HADDOCK, showing improved accuracy over ZDOCK.

Bioinformatics · Sep 27, 2024Peer-reviewedBioinformatics