Wenhan Guo

Local Microenvironments of capsomer variants in the PBCV-1

The paper replaces Type V capsomers with Type I capsomers in PBCV-1 to study their interactions with the local microenvironment, revealing differences in binding strength and salt bridge formation.

Electrostatic interactions in nucleosome and higher-order structures are regulated by protonation state of histone ionizable residue

The paper investigates how changes in histone protonation states affect nucleosome electrostatic potentials and interactions with partner proteins, and how cancer mutations influence these interactions.

How does the ion concentration affect the functions of kinesin BimC

This study investigates how ion concentration affects BimC's function by analyzing electrostatic interactions between BimC and microtubules using molecular dynamics simulations.

JRSeek: Artificial Intelligence Meets Jelly Roll Fold Classification in Viruses

JRSeek uses logistic regression on LLM embeddings to predict jelly roll folds in viral sequences with over 95% accuracy, showing the feasibility of sequence-based prediction.