Extrasynaptic localization is essential for α5GABAA receptor modulation of dopamine system function
Alexandra M. McCoy, Thomas D. Prévot, Md Yeunus Mian, Dishary Sharmin, Adeeba N. Ahmad, James Minton Cook, Etienne L. Sibille, Daniel J. Lodge
This study shows that extrasynaptic localization of 5GABAARs is critical for their ability to modulate dopamine system function, as shifting them to synaptic locations abolishes the effect of the 5-PAM GL-II-73.
eNeuro · Feb 27, 2024Peer-reviewedNeuroscience