Vanesa Nieto‐Estévez

APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids

This study shows APOE4 affects cortical neurodevelopment and network formation in human brain organoids by altering cell types, increasing cell death, and disrupting GABA signaling.

Dual effects of ARX poly-alanine mutations in human cortical and interneuron development

This study investigates the effects of ARX poly-alanine mutations in human brain organoids, revealing altered interneuron migration and cortical neuron development.

Buprenorphine exposure alters the development and migration of interneurons in the cortex

This study examines the effects of buprenorphine on interneuron development and migration in the cortex using fetal brain tissue, 3D cultures, and rodent models, finding persistent alterations into adulthood.