Phosphoinositide Depletion and Compensatory β-adrenergic Signaling in Angiotensin II-Induced Heart Disease: Protection Through PTEN Inhibition
Taylor L. Voelker, Maartje Westhoff, Silvia G. del Villar, Phung N. Thai, Nipavan Chiamvimonvat, Madeline Nieves‐Cintrón, Eamonn James Dickson, Rose Ellen Dixon
This study shows chronic AngII signaling disrupts cardiac phosphoinositide homeostasis, leading to cardiac dysfunction, but PTEN inhibition protects by preserving PI(3,4,5)P3 levels and reducing fibrosis.
bioRxiv · Feb 23, 2025 · PreprintPhysiology