Madeline Nieves‐Cintrón

This study identifies sex-specific cAMP signaling differences in vascular smooth muscle, showing female-specific SR cAMP pools and their hormonal regulation.

This paper identifies a mechanism by which amyloid beta potentiates CaV1.2 channels via β2AR, leading to synaptic dysfunction and neurotoxicity, and shows that disrupting this pathway prevents these effects.

This study shows chronic AngII signaling disrupts cardiac phosphoinositide homeostasis, leading to cardiac dysfunction, but PTEN inhibition protects by preserving PI(3,4,5)P3 levels and reducing fibrosis.

This study identifies the α1 adrenergic receptor - PKC - Pyk2 - Src signaling pathway as a mechanism boosting CaV1.2 channel activity and LTP in rodents.

The paper shows that Alpha-Actinin-1 enhances CaV1.2 channel activity by localizing it to specific sites and increasing its open probability.