Jacob Aunstrup Larsen

This study uses systematic K-to-Q mutagenesis to probe the energy landscape of α-Synuclein aggregation, identifying core residue mutations that alter free energy pathways and fibril polymorphism.

The paper shows RNA modulates assembly and activity of two -helical peptides, PSM3 and LL-37, through phase separation and aggregation dynamics, affecting virulence and host defense.