Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance
Atsushi Matsumoto, Akihito Inoko, Takuya Tanaka, Gen‐ichi Konishi, Waki Hosoda, Takahiro Kojima, Koji Ohnishi, Junichi Ikenouchi
The paper identifies that Snail-induced chemoresistance in cancer cells is linked to an imbalance in lipid metabolism, specifically through the repression of sphingomyelin biosynthesis and upregulation of ABCA1.
bioRxiv · Oct 22, 2024Cell Biology