Akihito Inoko

Targeting fatty acid synthase suppresses tumor development in NF2/CDKN2A-deficient malignant pleural mesothelioma

This study identifies FASN inhibition as a therapeutic strategy for NF2/CDKN2A-deficient MPM, showing reduced tumor growth in xenograft models.

Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

The paper identifies that Snail-induced chemoresistance in cancer cells is linked to an imbalance in lipid metabolism, specifically through the repression of sphingomyelin biosynthesis and upregulation of ABCA1.

Label-free visualization of ciliary rootlets in mouse brain

This paper introduces a label-free imaging method to visualize ciliary rootlets in mouse brain tissue, revealing their organized distribution and formation timing relative to primary cilia.

The yolk sac vasculature in early avian embryo provides a novel model for the analysis of cancer extravasation

The paper uses the yolk sac vasculature of early avian embryos to study cancer cell extravasation, showing distinct morphologies and dynamics through fluorescent labeling.

Coherent Raman microscopy detects nucleolar defects through amide I peak shifts originating from β-sheets: an application to visualizing ongoing cellular senescence

This paper introduces a label-free method using coherent Raman microscopy to detect nucleolar defects associated with cellular senescence by analyzing amide I peak shifts in nucleoli.

Genome-wide association meta-analysis identifies novel GP2 gene risk variants for pancreatic cancer in the Japanese population