Thorsten L. Schmidt

DNA Double-decker Ring Scaffolded Nanodisc for Self-assembly of Membrane Protein into Lipid Bilayer

This study introduces a DNA-based nanodisc scaffold for membrane protein assembly, demonstrating its compatibility with various lipids and detergents.

Falafel-Style Wrapping of AuNPs for DNA Origami Barcodes

This paper introduces a method to encapsulate gold nanoparticles within DNA origami tubes to improve barcode stability and functionality for multiplexed biomolecular detection.

Peptide-DNA Conjugates for Formation of Lipid Nanodiscs

This paper introduces DNA-templated peptide-DNA conjugates that form defined lipid nanodiscs with controlled structure and peptide arrangement.

DNA-Lipid Nanodiscs with a Polyethylene Glycol Interface

This paper introduces DNA-Lipid Nanodiscs (DLNs) with a PEG interface to study membrane proteins and lipid bilayers, showing effective shielding of hydrophobic mismatch through PEG-lipid interactions.

S-Alkyl-Phosphorothioate Modifications Reduce Thermal and Structural Stability of DNA Duplexes

This study shows that S-alkyl-phosphorothioate modifications reduce DNA duplex thermal and structural stability, despite reducing electrostatic repulsion.

Twist-Dependent Elastic Limits and Unwinding of Tightly Bent DNA

This study investigates the elastic limits of tightly bent DNA under torsional strain, finding that DNA can be bent to 3.0 nm without kinking when helical repeats are 11 bp/turn due to twist-bend coupling.