Christopher Maffeo

Expandable DNA-origami rings as a nanomechanical platform for studying disordered nucleoporins

This study uses DNA-origami rings to investigate FG-Nup interactions and their impact on NPC function, revealing how sequence and post-translational modifications affect protein behavior.

DNA: A Nanoscale Archimedes Screw

The paper demonstrates that rotating DNA duplexes can transport water and ions through a nanoscale pore, with cation transport driven by electrostatic interactions and potential applications in ion separation.

DNA-Lipid Nanodiscs with a Polyethylene Glycol Interface

This paper introduces DNA-Lipid Nanodiscs (DLNs) with a PEG interface to study membrane proteins and lipid bilayers, showing effective shielding of hydrophobic mismatch through PEG-lipid interactions.

Lossless end-to-end transport of small molecules through micron-length DNA nanochannels

The paper designs DNA nanochannels that allow small molecules to diffuse through micron-length channels, demonstrating controlled transport between compartments.

MrDNA: A multi-resolution model for predicting the structure and dynamics of nanoscale DNA objects

The paper introduces MrDNA, a multi-resolution simulation framework that predicts DNA nanostructure structures and dynamics with high accuracy, comparable to cryo-EM, in under 30 minutes.