Soumya Chandrasekhar

This study introduces a DNA-based nanodisc scaffold for membrane protein assembly, demonstrating its compatibility with various lipids and detergents.

This paper introduces DNA-templated peptide-DNA conjugates that form defined lipid nanodiscs with controlled structure and peptide arrangement.

This paper introduces DNA-Lipid Nanodiscs (DLNs) with a PEG interface to study membrane proteins and lipid bilayers, showing effective shielding of hydrophobic mismatch through PEG-lipid interactions.

This study shows that S-alkyl-phosphorothioate modifications reduce DNA duplex thermal and structural stability, despite reducing electrostatic repulsion.

This study investigates the elastic limits of tightly bent DNA under torsional strain, finding that DNA can be bent to 3.0 nm without kinking when helical repeats are 11 bp/turn due to twist-bend coupling.