RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation
Danya J. Martell, Hope E. Merens, Alexis Caulier, Claudia Fiorini, Jacob C. Ulirsch, Robert Ietswaart, Karine Choquet, Giovanna Graziadei, Valentina Brancaleoni, Maria Domenica Cappellini, Caroline Scott, Nigel A. Roberts, Melanie Proven, Noemi B. A. Roy, Christian Babbs, , L. Stirling Churchman
This study shows that SUPT5H mutations disrupt RNA polymerase II pausing, delaying erythroid differentiation and cell cycle progression in human cells.
Developmental Cell · Aug 15, 2023Peer-reviewedGenetic & Genomic Medicine