Robert Ietswaart

Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle

The paper quantifies RNA flow across subcellular compartments using TimeLapse-seq and identifies factors influencing mRNA life cycles.

Proximal termination generates a transcriptional state that determines the rate of establishment of Polycomb silencing

The paper develops a computational model to explain how proximal termination influences the rate of Polycomb silencing establishment at the FLC locus in Arabidopsis.

Early-stage lung adenocarcinoma is driven by an injury-associated, plastic cell state dependent on a KRAS-ITGA3-SRC axis

This study identifies an injury-associated, plastic cell state in early-stage lung adenocarcinoma driven by the KRAS-ITGA3-SRC axis, showing its role in tumor initiation and progression.

RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation

This study shows that SUPT5H mutations disrupt RNA polymerase II pausing, delaying erythroid differentiation and cell cycle progression in human cells.

GeneWalk identifies relevant gene functions for a biological context using network representation learning

GeneWalk identifies gene functions relevant to a biological context using network representation learning and validates it on RNA-seq and NET-seq data from human and mouse samples.