Author

Nigel A. Roberts

University of OxfordORCID 0000-0002-5091-3604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Marieke OudelaariD· 2 shared Damien J. DownesiD· 2 shared Douglas R. HiggsiD· 2 shared Jim R. HughesiD· 2 shared Afaf Helmy El-SagheeriD· 1 shared Alexis CaulieriD· 1 shared Arun ShivalingamiD· 1 shared Caroline L. HarroldiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

A. Marieke OudelaarORCID

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3 papers

Recent·Most cited

Active regulatory elements recruit cohesin to establish cell-specific chromatin domains.

Emily Georgiades, Caroline L. Harrold, Nigel A. Roberts, Mira T. Kassouf, Simone G. Riva, Edward Sanders, Damien J. Downes, Helena S. Francis, Joseph Blayney, A. Marieke Oudelaar, Thomas A. Milne, Douglas R. Higgs, Jim R. Hughes

The paper shows that active enhancers recruit cohesin to form cell-specific chromatin domains, using the alpha globin cluster as a model.

Scientific Reports · Apr 6, 2025Peer-reviewedGenomics

RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation

Danya J. Martell, Hope E. Merens, Alexis Caulier, Claudia Fiorini, Jacob C. Ulirsch, Robert Ietswaart, Karine Choquet, Giovanna Graziadei, Valentina Brancaleoni, Maria Domenica Cappellini, Caroline Scott, Nigel A. Roberts, Melanie Proven, Noemi B. A. Roy, Christian Babbs, , L. Stirling Churchman

This study shows that SUPT5H mutations disrupt RNA polymerase II pausing, delaying erythroid differentiation and cell cycle progression in human cells.

Developmental Cell · Aug 15, 2023Peer-reviewedGenetic & Genomic Medicine

Targeted high-resolution chromosome conformation capture at genome-wide scale.

Damien J. Downes, Matthew E. Gosden, Jelena M. Telenius, Stephanie J. Carpenter, Lea Nußbaum, Sara De Ornellas, Martin J. Sergeant, Chris Q. Eijsbouts, Ron Schweßinger, Jon Kerry, Nigel A. Roberts, Arun Shivalingam, Afaf Helmy El-Sagheer, A. Marieke Oudelaar, Tom P Brown, , Jim R. Hughes

The paper introduces a new method, NuTi Capture-C, that improves high-resolution chromosome conformation capture by reducing noise and increasing sequencing content, enabling reproducible genome-wide interaction profiles.

bioRxiv · Mar 2, 2020 · PreprintGenomics