ImmunologybioRxivPreprint
Aging-associated endo-lysosomal dysfunction drives inflammaging and neurodegeneration through the STING-IFN-I axis
Maria Öberg, Ivana Marić, Anneli Strömberg…·Anetta Härtlová
This study shows that LRRK2 gain of function accelerates aging by causing endo-lysosomal dysfunction, leading to inflammation and neurodegeneration via the STING-IFN-I axis.
DOI 10.64898/2026.03.15.711864