Aging-associated endo-lysosomal dysfunction drives inflammaging and neurodegeneration through the STING-IFN-I axis
Maria Öberg, Ivana Marić, Anneli Strömberg, Caitlyn Myers, Najmeh Saffarzadeh, Daniela Fabriková, Ivo Fabrik, Laia Rivas-Galvez, Karolina Patrycja Skibicka, Marzena Kurzawa‐Akanbi, Gesine Paul, Nelson O. Gekara, Anetta Härtlová
This study shows that LRRK2 gain of function accelerates aging by causing endo-lysosomal dysfunction, leading to inflammation and neurodegeneration via the STING-IFN-I axis.
bioRxiv · Mar 18, 2026 · PreprintImmunology