Author
University Hospital Hradec KrálovéORCID 0000-0002-3027-1253Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Maria Öberg, Ivana Marić, Anneli Strömberg…·Anetta Härtlová
This study shows that LRRK2 gain of function accelerates aging by causing endo-lysosomal dysfunction, leading to inflammation and neurodegeneration via the STING-IFN-I axis.
Aneta Houfková, Monika Schmidt, Ondřej Benek…·Kamil Musílek
This study shows that HSD10 overexpression causes cytotoxicity linked to mitochondrial damage, and this effect is worsened by Aβ-rich environments, with inhibitors showing potential therapeutic benefit.
Hana Hříbková, Veronika Pospíšilová, Kateřina Amruz Černá…·Dáša Bohačiaková
This study shows HSV-1 infection induces Aβ clustering and neurodegeneration pathways in iPSC-derived neurons, supporting the pathogen infection hypothesis for Alzheimer's disease.