Jianan Y. Qu

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond

This study evaluates transcranial optical window techniques for long-term brain imaging in mice, identifies skull regrowth as a key limitation, and proposes a glucocorticoid-based solution to extend imaging performance.

Dynamic Retinal Pathology in Glaucoma Progression Revealed by High-Resolution Functional Imaging in Vivo

This study uses high-resolution in vivo imaging to track dynamic retinal changes in glaucoma progression across different phenotypes.

Rapid adaptive optics enabling near noninvasive high-resolution brain imaging in awake behaving mice

This study develops MD-FSS for high-resolution brain imaging in awake mice, revealing differences in microglial states and vascular dynamics compared to anesthetized conditions.

Binocular integration of prey stimuli in the zebrafish visual system

The paper identifies binocular prey-responsive neurons in zebrafish and shows their role in encoding prey position through visual and motor inputs during hunting.

Toward Crosstalk-free All-optical Interrogation of Neural Circuits

This paper introduces an active pixel power control method to reduce crosstalk in two-photon optogenetics and calcium imaging, improving the accuracy of neural circuit analysis in zebrafish.

Microglial-Mediated Prevention of Axonal Degeneration in the Injured Spinal Cord: Insights from an In Vivo Imaging Study

This study shows microglia prevent axonal degeneration after spinal cord injury by wrapping injured axons, a process dependent on P2Y12 receptors and sodium channels.

Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window

This paper develops an optically cleared intervertebral window for long-term, high-resolution, inflammation-free in vivo imaging of mouse spinal cord dynamics.

High-resolution two-photon transcranial imaging of brain using direct wavefront sensing

This paper develops adaptive optics two-photon microscopy to achieve high-resolution transcranial imaging of brain neurons in living mice.

Adaptive optics two-photon endomicroscopy enables deep brain imaging at synaptic resolution over large volumes

This paper develops adaptive optics two-photon endomicroscopy to achieve high-resolution deep brain imaging and investigates neuronal plasticity in the hippocampus.