Negative allosteric modulation of cannabinoid CB1 receptor signaling suppresses opioid-mediated tolerance and withdrawal without blocking opioid antinociception
Vishakh Iyer, Shahin A. Saberi, Romario Pacheco, Emily Fender Sizemore, Sarah Stockman, Abhijit Kulkarni, Lucas Cantwell, Ganesh A. Thakur, Andrea G. Hohmann
This study shows that the CB1 receptor NAM GAT358 reduces opioid tolerance and withdrawal without impairing analgesia in mice.
bioRxiv · Jan 6, 2024 · PreprintNeuroscience