André Ferreira Castro

Temporal topology provides an interpretable framework for neuronal morphogenesis

The paper introduces TTMD, a framework using temporal topology to analyze neuronal morphogenesis, showing it can decode developmental stages and mutations in Drosophila neurons.

Synaptic density and relative connectivity conservation maintain circuit stability across development

The paper investigates how synaptic density and relative connectivity conservation maintain circuit stability during development in Drosophila using EM and computational modeling.

Physical Network Constraints Define the Lognormal Architecture of the Brain's Connectome

The paper analyzes eight connectomes and finds their degree distributions follow lognormal patterns, attributing this to a stochastic multiplicative process governing neuron size.

Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity

The paper proposes a mechanistic model that explains dendritic growth and synaptic organization through activity-independent cues and local activity-dependent plasticity, showing how these processes shape neuronal morphology and function.

Invariant synaptic density across species

The paper identifies a conserved synaptic density across species that stabilises neuronal responses by optimising wiring and conduction.

Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction

The paper investigates dendrite development in Drosophila c1vpda neurons, showing that sequential growth and stochastic retraction balance structural and functional requirements.

The branching code: a model of actin-driven dendrite arborisation

The paper develops a computational model to explain dendrite branchlet morphology in Drosophila neurons by analyzing actin-modulatory protein roles and dynamics.

A developmental stretch-and-fill process that optimises dendritic wiring

The paper develops a mathematical model of dendritic growth that optimizes wiring efficiency and space-filling through two complementary strategies.