Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer.
Liron Yoffe, Bhavneet Bhinder, Sung Wook Kang, Haoran Zhang, Arshdeep Singh, Hiranmayi Ravichandran, Geoffrey J. Markowitz, Mitchell Martin, Junbum Kim, Chen Zhang, Olivier Elemento, Wesley Tansey, Stewart Bates, Timothy E. McGraw, Alain Borczuk, , Vivek Mittal
This study identifies immune suppressive barriers in preinvasive lung cancer progression using single-cell analyses, revealing key cellular and spatial changes that could inform therapeutic strategies.
bioRxiv · Dec 31, 2024 · PreprintCancer Biology