Liron Yoffe

De novo lipogenesis controls antigen presentation and metastatic immune escape in triple-negative breast cancer.

FASN-driven lipogenesis sustains EGFR palmitoylation and PI3K-AKT-mTOR signaling, suppressing tumor MHC-I antigen presentation; blocking it curbs TNBC metastasis in mice via CD8 T cell recognition.

Propionate metabolism dysregulation promotes drug-tolerant persister cell survival in non-small cell lung cancer

This study shows that propionate metabolism dysregulation, through MMA accumulation and EMT activation, promotes drug-tolerant persister cell survival in NSCLC.

Tumor-draining lymph node derived CD8 T cells sustain durable systemic immunity after neoadjuvant IL-15 and PD-1 blockade

Neoadjuvant IL-15 with PD-1 blockade expands lymph node clonal diversity and preserves stem-like CD8 T cell features, yielding superior antitumor efficacy, durable memory, and reduced metastatic recurrence.

Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade

This study identifies two transcriptionally distinct CD8 T cell populations in tumor-draining lymph nodes that are shaped by neoadjuvant chemoimmunotherapy and influence tumor and blood T cell environments.

Simultaneous immunomodulation and epithelial-to-mesenchymal transition drives lung adenocarcinoma progression

This study profiles early-stage lung adenocarcinoma using multiplexed imaging mass cytometry to reveal two progression pathways: inflammation-driven and fibrosis-driven, with EMT masking malignant cell expansion.

Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer.

This study identifies immune suppressive barriers in preinvasive lung cancer progression using single-cell analyses, revealing key cellular and spatial changes that could inform therapeutic strategies.