Author

Vivek Mittal

Weill Cornell MedicineORCID 0000-0002-4764-7413Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Assay:scRNA-seq· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

Liron YoffeiD· 4 shared Arshdeep SinghiD· 3 shared Nasser Khaled AltorkiiD· 3 shared Olivier ElementoiD· 3 shared Timothy E. McGrawiD· 3 shared Bhavneet BhinderiD· 2 shared Geoffrey J. MarkowitziD· 2 shared Hiranmayi RavichandraniD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Liron YoffeORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

De novo lipogenesis controls antigen presentation and metastatic immune escape in triple-negative breast cancer.

Myung Soo Ko, Henry Withers, Divya Ramchandani, Jason McCormick, Sebastian E. Carrasco, Pius Amartey, Arshdeep Singh, Liron Yoffe, Glenn E. Simmons Jr., Guoan Zhang, Wen Hong Shen, Vivek Mittal

FASN-driven lipogenesis sustains EGFR palmitoylation and PI3K-AKT-mTOR signaling, suppressing tumor MHC-I antigen presentation; blocking it curbs TNBC metastasis in mice via CD8 T cell recognition.

bioRxiv · Oct 30, 2026 · PreprintCancer Biology✦ In-depth digest

Tumor-draining lymph node derived CD8 T cells sustain durable systemic immunity after neoadjuvant IL-15 and PD-1 blockade

Tatiana Cruz, Rachel Honigsberg, Geoffrey J. Markowitz, Dicle Özge Özgenel, Arshdeep Singh, Meixian Stephanie Tang, Stella A. Martomo, Liron Yoffe, Yongfeng He, Yang Bai, Jeegar P. Patel, Marissa M. Michael, Mitchell T. Martin, Timothy E. McGraw, Olivier Elemento, , Jonathan Villena‐Vargas

Neoadjuvant IL-15 with PD-1 blockade expands lymph node clonal diversity and preserves stem-like CD8 T cell features, yielding superior antitumor efficacy, durable memory, and reduced metastatic recurrence.

bioRxiv · Aug 12, 2025 · PreprintImmunology

Simultaneous immunomodulation and epithelial-to-mesenchymal transition drives lung adenocarcinoma progression

Junbum Kim, Hiranmayi Ravichandran, Liron Yoffe, Bhavneet Bhinder, Kyle Finos, Arshdeep Singh, Bradley B. Pua, Stewart Bates, Bevan Emma Huang, André F. Rendeiro, Vivek Mittal, Nasser Khaled Altorki, Timothy E. McGraw, Olivier Elemento

This study profiles early-stage lung adenocarcinoma using multiplexed imaging mass cytometry to reveal two progression pathways: inflammation-driven and fibrosis-driven, with EMT masking malignant cell expansion.

bioRxiv · Feb 19, 2025 · PreprintCancer Biology

Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer.

Liron Yoffe, Bhavneet Bhinder, Sung Wook Kang, Haoran Zhang, Arshdeep Singh, Hiranmayi Ravichandran, Geoffrey J. Markowitz, Mitchell Martin, Junbum Kim, Chen Zhang, Olivier Elemento, Wesley Tansey, Stewart Bates, Timothy E. McGraw, Alain Borczuk, , Vivek Mittal

This study identifies immune suppressive barriers in preinvasive lung cancer progression using single-cell analyses, revealing key cellular and spatial changes that could inform therapeutic strategies.

bioRxiv · Dec 31, 2024 · PreprintCancer Biology