Simultaneous immunomodulation and epithelial-to-mesenchymal transition drives lung adenocarcinoma progression
Junbum Kim, Hiranmayi Ravichandran, Liron Yoffe, Bhavneet Bhinder, Kyle Finos, Arshdeep Singh, Bradley B. Pua, Stewart Bates, Bevan Emma Huang, André F. Rendeiro, Vivek Mittal, Nasser Khaled Altorki, Timothy E. McGraw, Olivier Elemento
This study profiles early-stage lung adenocarcinoma using multiplexed imaging mass cytometry to reveal two progression pathways: inflammation-driven and fibrosis-driven, with EMT masking malignant cell expansion.
bioRxiv · Feb 19, 2025 · PreprintCancer Biology