Author

Lieke M Kuiper

Erasmus MCORCID 0000-0002-6888-1356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Charles NewcombiD· 1 shared Dan E. ArkingiD· 1 shared Daniela PuiuiD· 1 shared Eliseo GüallariD· 1 shared Jerome I. RotteriD· 1 shared Jiaqi XieiD· 1 shared Joel S. BaderiD· 1 shared Joost VerlouwiD· 1 shared

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2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Charles NewcombORCID

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1 paper

Recent·Most cited

Genetic & Genomic MedicineiSciencePeer-reviewedMay 6, 2025

Longitudinal change in mitochondrial heteroplasmy exhibits positive selection for deleterious variants

Lieke M Kuiper, Wen Shi, Joost Verlouw…·Dan E. Arking

This study shows that deleterious mitochondrial DNA mutations increase over time and are associated with higher mortality risk, suggesting positive selection rather than genetic drift.

13 citations

humanDNA methylation

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