Author
Johns Hopkins UniversityORCID 0000-0002-4471-9565Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
9 papers
Recent·Most cited
Xingyu Chen, Kei Nishimaki, Shuhei Tomoshige, Jill S. Chotiyanonta, Yuto Uchida, Bruce Alan Wasserman, Rebecca F. Gottesman, Eliseo Güallar, B. Gwen Windham, Kenichi Oishi
This study identifies spatial patterns of white matter hyperintensities (WMH) associated with cognitive decline in older adults using a community-based cohort.
bioRxiv · Oct 20, 2026 · PreprintNeuroscience
Lieke M Kuiper, Wen Shi, Joost Verlouw, Yun Soo Hong, Pascal Arp, Daniela Puiu, Linda Broer, Jiaqi Xie, Charles Newcomb, Stephen S. Rich, Kent D. Taylor, Jerome I. Rotter, Joel S. Bader, Eliseo Güallar, Joyce B. J. van Meurs, Dan E. Arking
This study shows that deleterious mitochondrial DNA mutations increase over time and are associated with higher mortality risk, suggesting positive selection rather than genetic drift.
iScience · May 6, 2025Peer-reviewedGenetic & Genomic Medicine
Yun Soo Hong, Sergiu Paşca, Wen Shi, Daniela Puiu, Nicole J. Lake, Monkol Lek, Meng Ru, Megan L. Grove, Anna E. Prizment, Corinne E. Joshu, Elizabeth A. Platz, Eliseo Güallar, Dan E. Arking, Lukasz P. Gondek
This study shows that mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms when added to existing CHIP-based models.
Nature Communications · Nov 22, 2024Peer-reviewedGenetic & Genomic Medicine
Vamsee Pillalamarri, Wen Shi, Conrad Say, Stephanie Y. Yang, John Lane, Eliseo Güallar, Nathan Pankratz, Dan E. Arking
Human Genetics and Genomics Advances · Sep 26, 2022Peer-reviewedGenetic & Genomic Medicine
Stephanie L. Battle, Yun Soo Hong, Wen Shi, Daniela Puiu, Vamsee Pillalamarri, Nathan Pankratz, Nicole J. Lake, Monkol Lek, Eliseo Güallar, Dan E. Arking
This study identifies that heteroplasmic mitochondrial mutations increase mortality risk and are linked to cancer incidence and outcomes, particularly leukemia.
medRxiv · Sep 20, 2022 · PreprintGenetic & Genomic Medicine
Stephanie Y. Yang, Christina A. Castellani, Ryan J. Longchamps, Vamsee Pillalamarri, Brian P O'Rourke, Eliseo Güallar, Dan E. Arking
Genome Research · Mar 1, 2021Peer-reviewedGenetics
Christina A. Castellani, Ryan J. Longchamps, Jason A. Sumpter, Charles Newcomb, John Lane, Megan L. Grove, Jan Bressler, Jennifer A. Brody, James S. Floyd, Traci M. Bartz, Kent D. Taylor, Penglong Wang, Adrienne Tin, Josef Coresh, James S. Pankow, , Dan E. Arking
This study identifies CpGs associated with mtDNA-CN and shows they influence disease-related phenotypes through nDNA methylation and gene expression changes.
Genome Medicine · Sep 28, 2020Peer-reviewedGenomics
Di Zhao, Traci M. Bartz, Nona Sotoodehnia, Wendy S. Post, Susan R. Heckbert, Álvaro Alonso, Ryan J. Longchamps, Christina A. Castellani, Yun Soo Hong, Jerome I. Rotter, Henry J. Lin, Brian P O'Rourke, Nathan Pankratz, John Lane, Stephanie Y. Yang, , Dan E. Arking
This study investigates the association between mitochondrial DNA copy number and risk of atrial fibrillation in three cohorts, finding an inverse relationship after adjustment for traditional risk factors.
BMC Medicine · Sep 15, 2020Peer-reviewedGenetics
Ryan J. Longchamps, Christina A. Castellani, Stephanie Y. Yang, Charles Newcomb, Jason A. Sumpter, John Lane, Megan L. Grove, Eliseo Güallar, Nathan Pankratz, Kent D. Taylor, Jerome I. Rotter, Eric Boerwinkle, Dan E. Arking
This study evaluates methods for estimating mitochondrial DNA copy number, finding that whole genome sequencing provides more accurate associations with known correlates than qPCR or microarray platforms.
PLoS ONE · Jan 31, 2020Peer-reviewedGenetics