Author

Ya Guan

Duke UniversityORCID 0000-0002-6889-4966Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Alexandra N. RindoneiD· 1 shared Connor D. AmelungiD· 1 shared Jennifer H. ElisseeffiD· 1 shared Jiyeon SongiD· 1 shared Prarthana Sanjay Daswani· 1 shared Sharon GerechtiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperBioengineering

Alexandra N. RindoneORCID

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1 paper

Recent·Most cited

Matrix stiffness induces endothelial network senescence

Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht

This study shows matrix stiffness induces endothelial cell senescence through a Notch-JNK-FOS pathway, supported by in vitro models and patient tissue analysis.

Advanced Science · Jul 2, 2026Peer-reviewedBioengineering