Sharon Gerecht

This study identifies ferroptosis as a vulnerability in stiff tumors mediated by YAP-SKP2 signaling, showing that stiff tumors are susceptible to ferroptosis induction despite chemotherapy resistance.

This study shows matrix stiffness induces endothelial cell senescence through a Notch-JNK-FOS pathway, supported by in vitro models and patient tissue analysis.

This study shows that γδ17 T cells influence fibrosis by altering ECM composition and vascularity through interactions with stromal cells.

This study shows that endothelial-pericyte interactions regulate angiogenesis through VEGFR2 signaling, and inhibiting VEGFR2 improves vascular stability in retinal diseases.

This study shows that gut microbiota dysbiosis from enteric infection increases immune cell recruitment to a distant biomaterial implant, affecting the foreign body response.

The paper develops an artery-on-chip model using human iPSC-derived cells to replicate arterial function and disease states, showing comparable tissue mechanics and disease phenotypes.

This study generates functional retinal endothelial cells from human iPSCs and demonstrates their ability to integrate into host vasculature and model retinal barrier diseases.