Alexandra N. Rindone

SEngEAR is a web platform for annotating senescent cells, visualizing communication networks, and comparing senescence signatures across datasets and contexts.

This study identifies distinct senescent cell populations in human fibroids and shows their role in ECM remodeling and vascular dysfunction through single-cell RNA sequencing and functional analysis.

This study shows matrix stiffness induces endothelial cell senescence through a Notch-JNK-FOS pathway, supported by in vitro models and patient tissue analysis.

The paper identifies distinct fibroblast and perivascular senescence subtypes in fibrosis using single-cell and spatial transcriptomics, showing their spatial organization and roles in fibrosis progression.

This study shows that γδ17 T cells influence fibrosis by altering ECM composition and vascularity through interactions with stromal cells.

The paper identifies Treg clonal expansion and immunosuppressive functions in fibrosis induced by synthetic implants, showing their role in modulating stromal cell behavior.

This study uses 3D imaging to analyze changes in the neurovascular architecture of the murine calvarium across aging, revealing age-related nerve loss and vascular changes.