Connor D. Amelung

This study identifies ferroptosis as a vulnerability in stiff tumors mediated by YAP-SKP2 signaling, showing that stiff tumors are susceptible to ferroptosis induction despite chemotherapy resistance.

This study shows matrix stiffness induces endothelial cell senescence through a Notch-JNK-FOS pathway, supported by in vitro models and patient tissue analysis.

This study shows that γδ17 T cells influence fibrosis by altering ECM composition and vascularity through interactions with stromal cells.

This study shows that gut microbiota dysbiosis from enteric infection increases immune cell recruitment to a distant biomaterial implant, affecting the foreign body response.

The paper develops an artery-on-chip model using human iPSC-derived cells to replicate arterial function and disease states, showing comparable tissue mechanics and disease phenotypes.