Krzysztof Wierbiłowicz

This study identifies an ADP-ribosyl-cysteine degron in PARP7 that is recognized by DTX2, leading to PARP7 degradation and affecting AR signaling in prostate cancer.

This paper introduces EvoBind-multimer, a deep learning framework for designing molecular glues from protein sequences, demonstrating its ability to recruit E3 ligases to oncoproteins and showing context-dependent functionality.

The paper identifies PARP7 as an enzyme that ADP-ribosylates the androgen receptor, marking it for degradation and creating negative feedback on AR-dependent gene expression.