An auto-generated ADP-ribosyl-cysteine degron drives DTX2-dependent turnover of PARP7
Chunsong Yang, Krzysztof Wierbiłowicz, Hyukjin Jang…·Bryce M. Paschal
This study identifies an ADP-ribosyl-cysteine degron in PARP7 that is recognized by DTX2, leading to PARP7 degradation and affecting AR signaling in prostate cancer.