David J. Wales

Decoding the Structural and Functional Impact of the Leukaemia-Associated A338V Mutation in GPR183

This study examines how the A338V mutation in GPR183 affects receptor function, showing preserved G protein activation but impaired GRK2 and β-arrestin2 recruitment.

Exploring RNA conformational ensembles in silico: progress and challenges

This paper reviews computational strategies for exploring RNA conformational ensembles, focusing on energy landscape-based approaches and atomistic simulations, and discusses challenges and future directions.

Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling

The paper identifies PARP7 as an enzyme that ADP-ribosylates the androgen receptor, marking it for degradation and creating negative feedback on AR-dependent gene expression.

Triplet-encoded prebiotic RNA aminoacylation

This paper demonstrates enzyme-free, sequence-dependent aminoacylation of RNA mimics, showing that terminal trinucleotides control aminoacylation selectivity.