Meng‐Qiu Dong

RNabel is a software tool for annotating tandem mass spectra of modified RNAs, supporting various modifications and formats, and providing quality metrics for spectral analysis.

TAIMS improves cross-link and low-abundance peptide identification by enhancing MS2 quality and sensitivity in proteomics.

This study identifies Npr1 as a nucleophagy receptor in fission yeast and shows that chromatin-nuclear envelope tethering inhibits nucleophagy.

This study shows that refeeding reverses aging-like phenotypes in C. elegans reproductive diapause by selectively activating the IRE-1 branch of UPRER and enhancing protein synthesis and folding.

The paper identifies two inhibitory mechanisms regulating MYRF-1 cleavage in C. elegans, showing their role in controlling developmental timing.

This paper describes a workflow for accurate de novo sequencing of antibody variable regions using mass spectrometry and open-source tools, achieving 100% accuracy in distinguishing leucine and isoleucine.

The paper introduces pLink-UBL, a software tool for identifying UBL modification sites on proteins and small-molecule substrates, and discovers spermidine as a small-molecule substrate of SUMO in fission yeast and mammals.

This study identifies TNGL-1 as a C. elegans TANGO1 family member that facilitates vitellogenin export from the ER by engaging cargo via a luminal domain.

The paper identifies subcompartments within C. elegans germ granules and maps perinuclear proteins to specific regions, revealing a novel D granule and the role of MIP-1/EDDG-1 in germ granule architecture.

The paper identifies multiple allosteric mechanisms regulating PDGFRβ kinase activity and shows their conservation in other type III RTKs, with implications for disease.

This study examines how terminal phosphate groups affect RNA oligonucleotide fragmentation in mass spectrometry, showing their impact on charge states and ion intensity, and suggests methods to improve analysis.

This study identifies SAD-1 kinase as a regulator of SYD-2/Liprin-α phase separation through phosphorylation, essential for presynaptic active zone assembly.

The paper develops a method to profile sphingolipids in C. elegans and identifies the functional roles of specific isozymes in sphingolipid biosynthesis.

This study characterizes the fragmentation behaviors of RNA oligonucleotides via CID-MS, revealing charge-state-dependent patterns and nucleobase loss mechanisms.

This study shows that hypodermal insulin/IGF-1 signaling regulates memory in C. elegans through non-autonomous signaling via the Notch pathway.

This study identifies GLH proteins' role in controlling Argonaute pathway specificity and promoting transgenerational silencing in C. elegans by binding to target mRNAs and amplifying small RNAs.

This study shows that SUMOylation of HDA-1 in C. elegans is required for Argonaute-directed transcriptional silencing by facilitating interactions with the NuRD complex and nuclear Argonaute HRDE-1/WAGO-9.

The paper shows PIE-1 promotes SUMOylation and activation of HDAC1 in C. elegans oogenesis, enhancing Argonaute-mediated surveillance.

The paper identifies a ternary complex involving Panx, dNxf2, and dNxt1 that suppresses transposon expression by inhibiting RNA export.

The paper identifies a PICS complex involved in piRNA processing and chromosome segregation in C. elegans, with distinct localization and function in different cellular contexts.

Open-pFind improves peptide identification in shotgun proteomics by handling complex modifications and increasing identification rates and speed.

This study identifies d-CMG intermediates during MCM helicase maturation, showing they are structurally distinct from MCM DHs and functionally immature compared to RPCs.

The paper identifies the USTC complex as essential for piRNA transcription in C. elegans, revealing its role in genome defense through specific binding to piRNA clusters.

This study shows that DAF-16, a transcription factor, activates gene expression during aging in C. elegans independently of insulin signaling, stabilizing the transcriptome against age-related stress.